Marriott Hotel and Convention Center • Bethesda, Maryland, USA • April 23-24, 2009
Chairs: Virginia Byers Kraus, MD, PhD, Michael Nevitt, PhD, MPH, and Linda Sandell, PhD
Session 1 – Overview
Goals of the Meeting and Overview of the Biomarkers Network
Linda Sandell, PhD
Washington University
Overview of Needs of the Field and EDRN Structure
Virginia Byers Kraus, MD, PhD
Duke University
Industry Perspective Overview of the Needs of the Field
Kevin Duffin, PhD
Eli Lilly
The Injured Knee - A Human Model for Early Stages of OA
Stefan Lohmander, MD, PhD
Lund University
Session 2 - Biomarkers – Current, New and Application to Clinical Trials
Osteoarthritis Biomarkers Update
Patrick Garnero, PhD
Synarc, Lyon, France
Vancouver OA Study
Jolanda Cibere, PhD
University of British Columbia
Biomarker Discovery through Genomic Studies
John Loughlin, PhD
Newcastle University
Review of Publically Available Sample Resources
Michael Nevitt, PhD, MPH
University of California- San Francisco
Session 3 – Methods of Multiplex Analysis of Biomarkers
Mass Spectroscopy Approaches to Multiplexing – SISCPA (Stable Isotope-labeled Standards with Capture on Anti-Peptide Antibodies)
Leigh Anderson, PhD
Plasma Proteome Institute
Predictive Modeling with “omics” Data for use in Clinical Trials Practice
Sheng Feng, PhD
Duke University
Session 4 – Advancing Public Availability of OA-Related Biomarkers Through Commercialization
Approach to Biomarker Development and Commercialization
David Johnston, PhD
LabCorp
Panel Led Discussion with Representatives of Industry Dealing with Validation and Commercialization of Biomarkers (Nordic, Synarc, Wyeth, etc)
Moderator: Morten Karsdal, PhD
Nordic Biosciences
Session 5 – Formulating Goals and Future Directions
Report on FDA OA Initiative - Biomarkers and Structure Working Groups
Virginia Byers Kraus, MD, PhD – Duke University
Phil Conaghan, MD, PhD, FRACP, FRCP – University of Leeds
Discussion of Working Group Structures for Carrying Initiatives Forward
Virginia Byers Kraus, MD, PhD – Duke University
Michael Nevitt, PhD, MPH – University of California – San Francisco