OA Biomarkers Workshop

A. INTRODUCTION (5 min) Linda Sandell

OARSI/AF/CAN/NIH OA Biomarkers Initiative

B. ARTHRITIS FOUNDATION TARGETED RESEARCH INITIATIVE IN OA

John Hardin

C. SCIENTIFIC PROGRAM Chair: Dick Heinegard

Overview: Where are we and what do we need to move ahead? Dick Heinegard

Session I. Molecular markers. Current assays – Where are we?

Collagen - Patrick Garnero
Aggrecan - Bruce Caterson
Other proteins Joanne Jordan/Dick Heinegard

Session II. Molecular markers. Next generation of markers – Where are we going?

Neoepitopes and New molecules - Morton Karsdal
Collagen Derivatives - Yves Henrotin
Markers of Inflammation in the Joint - Steve Abramson (slides unavailable)

Discussion for Sessions I and II

Session III. Tools from molecular markers that can be applied in imaging

Lessons from Gadolinium Agents - Deb Burstein
Immunocytochemistry - Thomas Aigner

Session IV. Clinical Evaluation of Markers

What clinical cohorts are available? what is missing and how can we fill the gaps? Stefan Lohmander